Role of plasticizer in membrane coated extended release oral
Membrane coating of immediate release dosage form is an effective means of producing an extended drug delivery system. Polymers when coated alone, have limited ability to form the rate controlling membrane with good mechanical properties. Addition of Download : Download high-res image (172KB) Download : Download full-size image Cited by (0)
Role of plasticizer in membrane coated extended release oral
Plasticizers have been used selectively for the development of numerous drug delivery systems such as buccal, transdermal, ocular, gastro retentive, tablet, and reservoir devices. Choice of the plasticizer plays a vital role in the performance of these formulations.
Role of plasticizer in membrane coated extended release oral
Addition of plasticizer is vital to the formation of a robust rate-controlling membrane. Plasticizers have the ability to interact with polymer chains, and provide desired flexibility, shock...
Role of plasticizer in membrane coated drug delivery system
Addition of plasticizer is vital to the formation of a robust rate-controlling membrane. Plasticizers have the ability to interact with polymer chains, and provide desired flexibility, shock resistance, and smoothness to resultant system. In addition to the plasticizing effect they also play an important role in modulating drug release profiles.
Recent progress in targeted delivery vectors based on
Cell membrane-coated nanoparticles, the cohesion of biological membrane and nanomaterials, remain both intricate biological functionalities of cell membranes and favorable physicochemical
- Why is membrane coating important in a drug delivery system?
- Membrane coating of immediate release dosage form is an effective means of producing an extended drug delivery system. Polymers when coated alone, have limited ability to form the rate controlling membrane with good mechanical properties. Addition of plasticizer is vital to the formation of a robust rate-controlling membrane.
- Why are plasticizers added to pharmaceutical polymers?
- e addition of a plasticizer into the formulation. Plasticizers are added to pharmaceutical polymers intending to ease the thermal workability, modifying the drug release from polymeric systems and improving the mechanical properties and surface properties of the dosage form (Felton, 2007; Lin et al., 2000; Wang et
- Why are plasticizers used in transdermal drug delivery systems?
- (Gal and Nussinovitch, 2009; Rajan et al., 2010). The reasons for the use of plasticizers in transdermal drug delivery systems are the improvement of film forming properties and the appearance of the film, decreasing the glass transition temperature of the polymer, preventing film cracking, increasing film flexibility and obtaini
- Does plasticizer affect osmotic drug delivery system permeability?
- Since plasticizer also impacts the permeability of the semi-permeable membrane, it is crucial to study the effect of plasticizer in coating systems for osmotic drug delivery system.
- Can plasticizers change the release rate of transdermal drug delivery systems?
- and polymer type used (Bharkatiya et al, 2010). It has been reported that, the plasticizers such as glycerine, sorbitol and polyethylene glycol can change release rate of the therapeutic components contained in the formula of transdermal drug delivery systems. Release rate of the drug can be adjusted by changing the type and concentration o
- Why are plasticizers important?
- Addition of plasticizer is vital to the formation of a robust rate-controlling membrane. Plasticizers have the ability to interact with polymer chains, and provide desired flexibility, shock resistance, and smoothness to resultant system. In addition to the plasticizing effect they also play an important role in modulating drug release profiles.
