Gelatin soft capsule formulation
Method Blend the gelatin, plasticizers* and water in the melter. Heat until the gelatin melts (end point 60°C). Vacuum for full de-aeration. Maturate for minimum 6 hours** at 60°C. Process the melt through your softgel equipment, dry to mass constancy (typically tumble dryer followed by tray drier at 20% ERH /25°C).
Sorbitol Based Soft Gel Plasticizers | Sorbitol Special - SPI
Sorbitol Special plasticizers are engineered to counter balance the stresses during processing and drying. SPI Pharma has the products and expertise to make a difference in your soft gel. Enabling Manufacturing Helps improve appearance of soft gel capsules Keep the shell soft and pliable, making it stable and easy to handle
POLYSORB l Partially Dehydrated Sorbitol Liquid l Roquette
POLYSORB 85/70/00 Partially dehydrated sorbitol liquid is a plasticizer in soft capsules and orally dissolving films. It can be used in pharmaceutical dosage forms. POLYSORB 85/70/00 is an aqueous solution of D-sorbitol and 1.4- sorbitans that has been developed by Roquette as a plasticizer for soft gelatine capsule applications.
Film Formers & Plasticizers for Softgels | Sorbitol Applications
Applications: Sorbiplast as a product is used for soft-gelatin capsules. It acts as a plasticizer providing the shell required elasticity, also imparts required flexibility. Ingredient (s): Sorbitol. Dosage Form: Softgels. Category: Film Formers & Plasticizers. Route of Administration (Grade): Oral. Pharmacopoeia Reference: In-house.
SORBITOL SPECIAL MDF 85 NF | Pharma & Healthcare | Azelis
Sorbitol Special plasticizers are sorbitan-sorbitol based soft gel plasticizers. They enhance the capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.
- What are sorbitan sorbitol special ® plasticizers?
- Sorbitol Special ® plasticizers are sorbitan-sorbitol based soft gel plasticizers. They enhance the capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.
- Does sorbitol plasticize gelatin?
- Sorbitol, on the other hand, is considered an indirect plasticizer, and other components of commercial sorbitol – sorbitan solutions might not have any plasticizing effect. A new experimental sorbitol-sorbitan solution (POLYSORB® 2.0, Roquette Frères, France), with an optimized composition, was tested for its capacity to plasticize gelatin.
- Does SPI Pharma make a difference in soft gel?
- SPI Pharma has the products and expertise to make a difference in your soft gel. Helps improve appearance of soft gel capsules Keep the shell soft and pliable, making it stable and easy to handle Results in smooth and shiny, premium-finish Increases success, reducing costs Reduce leaking Moisture content maintained Capsule breakage avoided
- Why do you need a special plasticizer for a soft capsule?
- The formation of a soft capsule requires the use of a non-volatile plasticizer in addition to water to guarantee the mechanical stability. Sorbitol Special plasticizers are engineered to counter balance the stresses during processing and drying. SPI Pharma has the products and expertise to make a difference in your soft gel.
- What is sorbitol sorbitan?
- The nature of the plasticizer system has an important influence on capsule production, its properties and the capsules’ evolution during storage. A sorbitol-sorbitan solution with a selected composition used as plasticizer results into more flexible gelatin capsules. It is an efficient substitute to glycerin for hydrophilic fills.
- Which sorbitol-sorbitan solution is used to make Polysorb® capsules?
- The commercial plasticizer POLYSORB® 85/70/00 (sorbitol-sorbitan solution, Roquette Frères, France) and glycerin (Arcane, France) were used as benchmarks. Main attention was paid on important application parameters such as the flexibility of the capsules and its drying speed.
