POLYSORB l Partially Dehydrated Sorbitol Liquid l Roquette
POLYSORB 85/70/00 Partially dehydrated sorbitol liquid is a plasticizer in soft capsules and orally dissolving films. It can be used in pharmaceutical dosage forms. POLYSORB 85/70/00 is an aqueous solution of D-sorbitol and 1.4- sorbitans that has been developed by Roquette as a plasticizer for soft gelatine capsule applications.
Sorbitol Based Soft Gel Plasticizers | Sorbitol Special - SPI Pharma
Sorbitol Special plasticizers are engineered to counter balance the stresses during processing and drying. SPI Pharma has the products and expertise to make a difference in your soft gel. Enabling Manufacturing Helps improve appearance of soft gel capsules Keep the shell soft and pliable, making it stable and easy to handle
Gelatin soft capsule formulation
Method. Blend the gelatin, plasticizers* and water in the melter. Heat until the gelatin melts (end point 60°C). Vacuum for full de-aeration. Maturate for minimum 6 hours** at 60°C. Process the melt through your softgel equipment, dry to mass constancy (typically tumble dryer followed by tray drier at 20% ERH /25°C).
Comparative Evaluation of Commonly Employed Plasticizers in Soft
gel mass on reaching the end point is of significant interest to the formulator. CONCLUSION(S) Sorbitol-sorbitan solutions are widely used as plasticizers in the manufacture of soft gelatin capsules. This study confirms their functional advantage through a rank order of soft gel plasticizers in terms of their drying behavior and associated time
Sorbitol Function | Film Formers & Plasticizers
Sorbitol Special is an effective plasticizer for soft gel formulations which makes soft shells more robust. These grades reduce drying time, driving productivity and also enhance the gloss of capsules for a premium appearance. Ingredient (s): Sorbitol Dosage Form: Softgels Category: Film Formers & Plasticizers Route of Administration (Grade): Oral
- What are sorbitan sorbitol special ® plasticizers?
- Sorbitol Special ® plasticizers are sorbitan-sorbitol based soft gel plasticizers. They enhance the capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.
- Are sorbitol special plasticizers soluble in peg?
- Sorbitol Special plasticizers are not soluble in PEG. They will not leach into the PEG-based fills of the capsule unlike standard plasticizers such as glycerin that are soluble in PEG. Using Sorbitol Special can result in a more stable shell, reducing failures from leaking capsules and increasing quality and output.
- How does sorbitol special work?
- Sorbitol Special can also inhibit blooming — white discoloration on the surface of the capsule. Left alone, PEG can react with gelatin plasticizers, allowing moisture to migrate away from the shell, causing the capsule to break down. Sorbitol Special plasticizers can help keep moisture well-adjusted to help prevent this failure.
- What is sorbitol sorbitan?
- The nature of the plasticizer system has an important influence on capsule production, its properties and the capsules’ evolution during storage. A sorbitol-sorbitan solution with a selected composition used as plasticizer results into more flexible gelatin capsules. It is an efficient substitute to glycerin for hydrophilic fills.
- What is a soft gelatin capsule?
- In manufacturing soft gelatin capsules, SPI Pharma’s grades of specialty plasticizers serve as a humectant and plasticizer for the capsule shell. They function to keep the shell soft and pliable, making it stable and easy to handle. These qualities result in a smooth, shiny, premium-finished appearance that is desirable to consumers.
- Does sorbitol plasticize gelatin?
- Sorbitol, on the other hand, is considered an indirect plasticizer, and other components of commercial sorbitol – sorbitan solutions might not have any plasticizing effect. A new experimental sorbitol-sorbitan solution (POLYSORB® 2.0, Roquette Frères, France), with an optimized composition, was tested for its capacity to plasticize gelatin.
