Effect of Plasticizer Type on Tensile Property and In Vitro
Effect of Plasticizer Type on Tensile Property and In Vitro Indomethacin Release of Thin Films Based on Low-Methoxyl Pectin Authors Pensak Jantrawut 1 , Tanpong Chaiwarit 2 , Kittisak Jantanasakulwong 3 , Claire Hélène Brachais 4 , Odile Chambin 5 Affiliations
Effect of Plasticizer Type on Tensile Property and In Vitro
The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor; propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20–40% w/w) on mechanical and thermal properties of LMP films as well as on in vitro release of indomethacin were evaluated.
STUDIES ON EFFECT OF PLASTICIZER ON INVITRO RELEASE AND
The release and permeation studies were carried out for developing transdermal therapeutic systems with chlorpheniramine maleate (CPM). The patches were prepared with Eudragit E100 with/without polyvinyl pyrrolidone (PVP) and dibutyl phthalate (DBP) as well as dibutyl sebacate (DBS) as the plasticizer in different compositions. Thickness, tensile strength, modulus of elasticity, drug content
Effect of Plasticizer Type on Tensile Property and In Vitro
The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor; propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20–40% w/w) on mechanical and thermal...
In Vitro Release Study of the Polymeric Drug Nanoparticles
The in vitro release study is a critical test to assess the safety, efficacy, and quality of nanoparticle-based drug delivery systems, but there is no compendial or regulatory standard. The variety of testing methods makes direct comparison among different systems difficult. We herein proposed a nov
- Do different plasticizer types affect mechanical and thermal properties of LMP films?
- The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor; propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20–40% w/w) on mechanical and thermal properties of LMP films as well as on in vitro release of indomethacin were evaluated.
- Which plasticizers are used in pectin films?
- In this study, different plasticizers including glycerol (Gly), sorbitol (Sor), propylene glycol (PG) and polyethylene glycol 300 (PEG 300), in five concentrations, were tried in pectin films and the effect on tensile and thermal properties and then on indomethacin in vitro release of LMP films were evaluated. 2. Materials and Methods 2.1.
- How does plasticizer content affect drug release profiles?
- The release profiles of TH from the coated pellets were influenced by the type and amount of plasticizer and of coating material, and by the ratio polymer-plasticizer. For both types of coating, the drug release rate decreased with increasing plasticizer content.
- Can Plasticizers improve drug release?
- Release was evaluated using surface normalized dissolution testing. Differential scanning calorimetry was used to measure glass transition temperature and water vapor sorption was performed on select samples. The presence of a plasticizer at 5% w/w for ATZ and 10% w/w for LED ASDs, led to improved drug release.
- How does plasticizer concentration affect film elongation?
- The increasing of plasticizer concentration from 20% to 40% led to a significant increase in the film elongation: 17.56% to 32.75% for Gly-plasticized films. For Sor-plasticized and PG-plasticized films, the elongation increased from 21.52% to 22.31% and from 18.80% to 27.23%, respectively.
- Are lipophilic and hydrophilic plasticizers more effective at improving drug release?
- In particular, it is notable that the lipophilic plasticizers appear more effective at improving release at higher drug loadings than hydrophilic plasticizers. This suggests that their interaction with and impact on the drug may also be important factors, particularly in the presence of water.
