Analytical methods for the determination of DEHP plasticizer
Several replacement plasticizers, so-called “alternative to DEHP plasticizers” were incorporated into the MDs. Nowadays, the risk of exposure to these compounds for hospitalized patients, particularly in situations classified “at risk”, has not yet been evaluated, because migrations studies, providing sufficient exposure and human toxicity data have not been performed.
Urinary Concentrations of Major Phthalate and Alternative Plasticizer
Di-(2-ethylhexyl) phthalate (DEHP), one of the most extensively used phthalates, has been rapidly ... Exposure profiles and risks of phthalates and alternative plasticizers were assessed for the first time among children of Saudi Arabia, Indonesia, and Thailand.
Urinary Concentrations of Major Phthalate and Alternative Plasticizer
The hazard index (HI) derived for the plasticizers with antiandrogenicity based reference doses (RfD AA) was >1 in 86%, 80%, and 49% of the Saudi, Indonesian, and Thai children, respectively. DEHP was identified as a common major risk driver for the children of all three countries, followed by DnBP and DiBP depending on the country.
In vitro cytotoxic effects of DEHP-alternative plasticizers and their
The metabolization of plasticizers increases their cytotoxicity. For example, in the literature, MEHP, the DEHP bioactive metabolite (Frederiksen et al., 2007), was shown to be 10 times more potent than DEHP (Huber et al., 1996). MEHP is a well-known activator of the PPAR family of nuclear receptors (Hurst and Waxman, 2003, Maloney and Waxman
Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP)
Di(2-ethylhexyl)phthalate (DEHP) is a widely used plasticizer to render poly(vinyl chloride) (PVC) soft and malleable. Plasticized PVC is used in hospital equipment, food wrapping, and numerous other commercial and industrial products.
- How much DEHP is in plastic?
- Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide.
- What is DEHP used for?
- Due to its suitable properties and the low cost, DEHP is widely used as a plasticizer in manufacturing of articles made of PVC. Plastics may contain 1% to 40% of DEHP. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks.
- Why is DEHP a phthalate?
- These chemicals are primarily used in the manufacturing of different plastics to improve their flexibility and workability. While DEHP was once a predominant phthalate, its use has dwindled in contemporary years because of rising troubles about its probable health impacts.
- Are alternative plasticizers a health based human biomonitoring (HBM-I)?
- Among alternative plasticizers, urinary DEHTP metabolites were detected at levels comparable to those of DEHP metabolites or higher among the Saudi children, and about 4% of the Saudi children exceeded the health based human biomonitoring (HBM)-I value.
- Which phthalate plasticizer is used in medical devices?
- DEHP is the most common phthalate plasticizer in medical devices such as intravenous tubing and bags, IV catheters, nasogastric tubes, dialysis bags and tubing, blood bags and transfusion tubing, and air tubes. DEHP makes these plastics softer and more flexible and was first introduced in the 1940s in blood bags.
- What is the hazard index of plasticizers in Indonesian children?
- Urinary DEHP metabolite concentrations were the highest in the Indonesian children. The hazard index (HI) derived for the plasticizers with antiandrogenicity based reference doses (RfD AA) was >1 in 86%, 80%, and 49% of the Saudi, Indonesian, and Thai children, respectively.
