The Influence of Plasticizer on Heat-Humidity Curing
When plasticizer was incorporated in the coating formulations, heat-humidity curing effectively improved the acid resistance of the coated films at all plasticizer levels investigated. The minimum plasticizer level required to obtain enteric release profiles for heat-humidity cured beads coated at an outlet coating temperature of 46°C was 15%.
The influence of plasticizer on heat-humidity curing
The minimum plasticizer level required to obtain enteric release profiles for heat-humidity cured beads coated at an outlet coating temperature of 46 degrees C was 15%. This limit was further decreased when the beads were coated at a lower temperature due to a less plasticizer loss at the lower coating temperature.
Influence of plasticizer (triphenyl phosphate) loading on
Important curing conditions in the processing are temperature, relative humidity, and time and are strongly dependent on nature of plasticizer and its %age. It was observed that the mobility of macromolecules increases on increasing temperature and as a consequence coalescence of polymer particles took place, also relative humidity helps in
The influence of plasticizer on heat-humidity curing
The influence of plasticizer on heat-humidity curing of cellulose acetate phthalate coated beads. Sign in | Create an account. https://orcid.org. Europe PMC
Aqueous polymeric coatings: New opportunities in drug
When using a water-soluble plasticizer (TEC), increasing the harshness of the conditions (time, temperature, and relative humidity) caused the drug release rate to decrease, for all coating levels. On increasing the temperature, time, and humidity, better film formation was achieved, and drug release decreased.
- Does coating temperature affect curing?
- These results indicated that curing was dependent on the coating temperature. The residual moisture retained in the coating layer of beads coated at 32°C may play a role in the coalescence during curing.
- Do aliquots of coated beads cured at different temperatures?
- Curing conditions An aliquot of coated beads from batches H–K were cured at 60°C for 12 h to study the effect of curing on beads coated at different temperatures.
- Can talc be used for curing in humid conditions?
- For curing involving moisture, beads were blended with 2% talc to prevent sticking, if required, and placed in the desiccators containing saturated salt solutions. Curing in the presence of different relative humidities was investigated with selected runs (batches H and K).
