Exposure to DBP induces the toxicity in early development and
Dibutyl phthalate (DBP) is one of the most ubiquitous plasticizers used worldwide and has been frequently detected in soil, water, atmosphere, and other environmental media. DBP has become a ubiquitous environment contaminant and causes serious pollution.
Hazards of diisobutyl phthalate (DIBP) exposure: A systematic
There was robust evidence that DIBP causes male reproductive toxicity. Male rats and mice exposed to DIBP during gestation had decreased testosterone and adverse effects on sperm or testicular histology, with additional phthalate syndrome effects observed in male rats.
The reproductive toxicity and potential mechanisms of combined
Abstract Dibutyl phthalate (DBP) and diisobutyl phthalate (DiBP) are phthalate compounds frequently detected in the environment. Despite increasing awareness of their toxicity in human and animals, the male reproductive toxicity of their combined exposure remains elusive.
Fe-Activated Peroxymonosulfate Enhances the Degradation of Dibutyl
Here, we found that dibutyl phthalate (DBP) could be degraded on moist quartz sand (QS, crystal, a typical soil constituent) during stirring, and the removal rate reached 57.2 ± 3.1% after 8 h of reaction.
Guideline on the use of phthalates as excipients in human medicinal
Dibutyl phthalate (DBP) DBP was associated with an anti-androgenic effect in a human cell line as it inhibited the binding of dihydrotestosterone to the androgen receptor with an IC 50 of 74 M (Christen et al. 2010). DBP was devoid of oestrogenic activity in vitro (Lee et al. 2012).
- Does di-n-butyl phthalate cause germ cell toxicity?
- Provided by the Springer Nature SharedIt content-sharing initiative Di-n-butyl phthalate (DBP) is a kind of ubiquitous chemical linked to hormonal disruptions that affects male reproductive system. However, the mechanism of DBP-induced germ cells toxicity remains unclear.
- What is di-n-butyl phthalate (DBP)?
- Di-n-butyl phthalate (DBP), a well-known EDC, is widely used in industrial productions. The use or disposal of plastics leads to ubiquitous exposure to DBP, which adversely affects male reproductive health 2.
- Does di-n-butyl phthalate cause oxidative damage?
- Zhou, D. et al. Di-n-butyl phthalate (DBP) exposure induces oxidative damage in testes of adult rats. Syst. Biol. Reprod. Med. 56, 413–419 (2010). Qin, Z. et al. Protective effects of sulforaphane on di-n-butylphthalate-induced testicular oxidative stress injury in male mice offsprings via activating Nrf2/ARE pathway.
- Are DBP and DIBP toxic to HPT axis toxicity?
- Both the levels of T3 and T4 increased and upregulation of tg, ttr, and dio2 transcription demonstrated that DBP and DiBP were toxic to the HPT axis toxicity, The additive index method was used to evaluate DBP and DiBP joint effects. A synergistic effect was observed in DBP and DiBP mixtures.
- Is DBP a risk factor for human health?
- DBP’s potential risk to human health has been, and continues to be, investigated. Researchers have evaluated its developmental and reproductive effects, as well as sensitization, systemic effects, and genetic toxicity.
- Is DIBP a toxicity hazard?
- The concentrations of DiBP were in the same order of magnitude as those of DBP, indicating that DiBP is one of the most prevalent PAEs. However, there are few relevant toxicity studies on the mechanism of action, or the biochemical pathways involved in aquatic animals’ exposure to DBP and DiBP.
