The mechanisms of toxicity of Dibutyl Phthalate (DBP)
DBP is an example of an environmental antiandrogen that disrupts androgen-regulated male sexual differentiation without interacting directly with the androgen receptor (AR) in vitro, as does flutamide. 449 Highly Influential View 4 excerpts, references background
The Mechanisms of Toxicity of Dibutyl Phthalate (DBP)
The Mechanisms of Toxicity of Dibutyl Phthalate (DBP) in Cultured Cells A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Science in Biochemistry In the Department of Chemistry at the University of Canterbury New Zealand By Nicholas McKitterick University of Canterbury 2016
Phthalate toxicity mechanisms: An update - ScienceDirect
In this study, an in vitro culture system of rat insulinoma (INS-1) cells was established to explore the effect of DBP on insulin synthesis and secretion and the potential mechanisms. INS-1 cells were cultured in RPMI-1640 medium containing 10% fetal bovine serum and treated with 15, 30, 60 and 120 μmol/L of DBP and dimethyl sulfoxide (vehicle
Phthalates Toxicity - StatPearls - NCBI Bookshelf
The toxicity of phthalates has gained increasing attention as studies have begun to show deleterious endocrine and metabolic side effects associated with various subcategories of phthalates. This has led to regulatory action, banning different phthalates that have been shown to cause harm.
The mechanisms of toxicity of Dibutyl Phthalate (DBP)
The LC-540 model system is able to produce detectable quantities of testosterone with and without external stimulation in culture. The metabolism of DBP did not produce any potentially estrogenic metabolites; however, the LC-540 Phase I and Phase II processes were identified. DBP appears to be slightly estrogenic and promotes growth of MCF-7 cells.
- Does di-n-butyl phthalate cause germ cell toxicity?
- Provided by the Springer Nature SharedIt content-sharing initiative Di-n-butyl phthalate (DBP) is a kind of ubiquitous chemical linked to hormonal disruptions that affects male reproductive system. However, the mechanism of DBP-induced germ cells toxicity remains unclear.
- Is dibutyl phthalate a risk factor for neurodegenerative disorders?
- Mitochondrial susceptibility indicated the risks of neurodegenerative disorders. Dibutyl phthalate (DBP) is commonly applied plasticizer in plastic products such as face masks, easily leaches or migrates into environment and its widespread contamination posed profound health risks.
- Does DBP toxicity affect mitochondrial susceptibility?
- Further concerns rise regarding to the toxicity of DBP at subcellular level, while little is known about the ranging effects on mitochondrial susceptibility. Present study investigated the mitochondrial impairments with implicated cell death upon DBP exposure on zebrafish cells.
- Does di-n-butyl phthalate cause oxidative damage?
- Zhou, D. et al. Di-n-butyl phthalate (DBP) exposure induces oxidative damage in testes of adult rats. Syst. Biol. Reprod. Med. 56, 413–419 (2010). Qin, Z. et al. Protective effects of sulforaphane on di-n-butylphthalate-induced testicular oxidative stress injury in male mice offsprings via activating Nrf2/ARE pathway.
- What is di-n-butyl phthalate (DBP)?
- Di-n-butyl phthalate (DBP), a well-known EDC, is widely used in industrial productions. The use or disposal of plastics leads to ubiquitous exposure to DBP, which adversely affects male reproductive health 2.
- Does di-n-butyl phthalate affect genital tubercle development?
- The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate. Toxicology 293, 53–58 (2012). Chen, X. et al. Prenatal exposure to di-n-butyl phthalate disrupts the development of adult Leydig cells in male rats during puberty.
