TEC Plasticization of Topical Polymeric Films | SpringerLink
The degree of homogeneity and the mechanical properties of topical polymeric films for drug delivery are vital to their efficacy. The dispersal of plasticizer and the solubility of the drug within the films (the homogeneity of their distribution) affect their function; phase separations have been shown to trigger drug crystallization [] and the efficacy (bioavailability) and stability of the
Topical Polymeric Films and Transdermal Patches | BASF Pharma
While topical polymeric films form intact, transparent drug delivery systems on the skin surface, transdermal patches utilize adhesive matrix technology to deliver active pharmaceutical ingredients through the skin. Due to their benefits such as physical barrier formation, ease of application, and reduced dosing frequency, topical polymeric
Film forming systems for topical and transdermal drug delivery
The films are formed in a Petri dish or on an excised pig ear skin. Film-formation is evaluated and rated as complete and uniform, incomplete or non-uniform, with or without precipitation of the film-forming polymer. The cosmetic aspects of the film are given in terms of transparency or opaque, sticky or dry, peelable or non-peelable [55]. 8.2
Film-Forming Systems in Topically Administered
Polymeric films can be previously prepared or formed in situ, after application of a film-forming system (FFS) used as a drug dosage form or to protect a dosage form or as a drug dosage form...
Polymeric Plasticizers
Polymer plasticizers or polyadipates are polyesters of aliphatic dicarboxylic acids. BASF manufactures and markets the following polymer plasticizers for special applications: Palamoll products
- What is a topical film forming system?
- Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue.
- Why are plasticizers used in film forming systems?
- Plasticizers Plasticizers are used in the film forming systems to impart flexibility to the film and improve the tensile strength of the film formed. The plasticizer used should be compatible with the polymers used and should have low skin permeability.
- Which polymer is used as a plasticizer?
- Triethyl citrate and polysorbate 80 were used as plasticizers in various concentrations. The combination of water-soluble and water-insoluble polymers without using volatile solvent for formulation created the basis for further research in the field of film-forming emulsions [83, 84].
- What are the benefits of topical polymeric films & transdermal patches?
- Due to their benefits such as physical barrier formation, ease of application, and reduced dosing frequency, topical polymeric films and transdermal patches are often associated with improved patient compliance.
- Which polymers are best suited to film-forming systems?
- Small polymers with a low molecular weight are usually better suited to film-forming systems. The viscosity of the formulation increases during the solvent evaporation process, even more so for polymers with a high molecular weight.
- How does a polymeric solution form a film?
- In this the polymeric solution is applied to the skin as a liquid or sprayed on the skin and forms an almost transparent film by solvent evaporation . The film forming sprays/solutions are made up of four main components – drug, solvent systems i.e. volatile and non-volatile vehicles, polymers and penetration enhancers.
