Phthalate and di- (2-ethylhexyl) adipate (DEHA) intake by German
Abstract Phthalates as well as di- (2-ethylhexyl) adipate (DEHA) are used as plasticizers in diverse applications and are of toxicological concern. The study was conducted with a study population of 25 German subjects aged between 15 and 21 months.
Toxic potential of the plasticizer Di(2-ethylhexyl) phthalate in the
Abstract Although human toxicity from exposure to the plasticizer di (2-ethylhexyl) phthalate (DEHP) is unknown, reports of animal toxicity from DEHP have stimulated extensive toxicological studies.
Exposure of patients to di(2-ethylhexy)phthalate (DEHP) and its
Due to the toxicological potential of DEHP, the inner exposure of patients with this plasticizer is a strong matter of concern as many studies have shown a high leaching potential of DEHP into blood. In this study, the inner DEHP exposure of patients undergoing ECMO treatment was investigated.
Glutathione peroxidase 6 from Arabidopsis thaliana as potential
As a most abundant plasticizer, Di-(2-ethylhexyl) phthalate (DEHP) has been widely used in agriculture with an associated potential toxicity to many species including plants via the production of the excessive reactive oxygen species (ROS). However, the potential toxic mechanisms of the plasticizer
Exposure of patients to di(2-ethylhexy)phthalate (DEHP) and its
Due to the toxicological potential of DEHP, the inner exposure of patients with this plasticizer is a strong matter of concern as many studies have shown a high leaching potential of DEHP into blood. In this study, the inner DEHP exposure of patients undergoing ECMO treatment was investigated.
- What is plasticizer Di 2 ethylhexyl phthalate (DEHP)?
- The plasticizer di (2-ethylhexyl) phthalate (DEHP) has been widely used in the manufacture of polyvinyl chloride-containing products such as medical and consumer goods. Humans can easily be exposed to it because DEHP is ubiquitous in the environment.
- Is Di(2 ethylhexyl phthalate) carcinogenic?
- The commonly used plasticizer di(2-ethylhexyl) phthalate (DEHP) was recently tested for chronic toxic potential by incorporation into the diet of rats and mice for approximately 2 yr. Upon reviewing the test results, the sponsoring organization concluded that DEHP was carcinogenic to the rats and mi …
- Are DEHP plasticizers a toxicity hazard?
- Exposure to DEHP plasticizers leads to toxicity in essential organs of the body through various mechanisms. The main objective of this review article is to focus on the DEHP-induced endoplasmic reticulum (ER) stress pathway implicated in the testis, brain, lungs, kidney, heart, liver, and other organs.
- What is di-2-ethylhexyl phthalate (DEHP)?
- Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products.
- How does DEHP cause toxicity?
- In recent years, toxicity studies on DEHP have increased abruptly. DEHP imparts toxicity through various pathological mechanism including endoplasmic reticulum (ER) stress pathways, PPAR-related pathways, oxidative stress and inflammation, Ca 2+ homeostasis disturbances in mitochondria (Lin et al., 2023; Ito et al., 2019).
- How does ER stress affect DEHP toxicity?
- ER stress pathway is the underlying mechanism that elicits DEHP toxicity. Along with ER stress, other signaling pathways have also been reported. The plasticizer di- (2-ethylhexyl)-phthalate (DEHP) is the most significant phthalate in production, usage, and environmental occurrence.
