Use of a Plasticizer for Physical Stability Prediction
As a result, we were able to predict the physical stability of the unplasticized ASD. This approach is especially useful for ASDs with high polymer content where drug crystallization is extremely slow at the relevant storage temperature. Supporting Information
Use of a Plasticizer for Physical Stability Prediction
Utilizing glycerol as a plasticizer, an accelerated physical stability testing method of amorphous solid dispersions (ASDs) was developed. The acceleration in crystallization brought about by glycerol expedited the determination of the coupling between molecular mobility and crystallization.
The use of a plasticizer for physical stability prediction
Utilizing glycerol as a plasticizer, an accelerated physical stability testing method of amorphous solid dispersions (ASD) was developed.
Use of a Plasticizer for Physical Stability Prediction
Use of a Plasticizer for Physical Stability Prediction of Amorphous Solid Dispersions Full Record Related Research Abstract Utilizing glycerol as a plasticizer, an accelerated physical stability testing method of amorphous solid dispersions (ASDs) was developed.
Predicting physical stability of solid dispersions by machine
Currently, the physical stability of SDs needs at least three months to six months by trial-and-error experiments, which is time-consuming and unpredictable. If unsuccessful, the long cycle has to be re-tested. Moreover, the mechanism of physical stability of solid dispersions is still poorly understood [ 14 ].
- Do plasticizers affect the physical stability of ASDs?
- The effect of plasticizers on the physical stability of ASDs was also assessed by employing two different types of ASDs based on probucol and Drug-1 as model BCS Class II drugs.
- Do plasticizers in film coats affect the physical stability of ASDs?
- In this study, we demonstrate that plasticizers present in film coats can have a detrimental impact on the physical stability of ASDs. We systematically compared two frequently used plasticizers in film coats: triacetin and polyethylene glycol 3350 (PEG 3350).
- Do amorphous solid dispersions improve bioavailability of drugs?
- Amorphous solid dispersions (ASDs) have been extensively utilized to improve the bioavailability of drugs that have low aqueous solubility. The influence of different excipients on the conversion of amorphous drugs into their crystalline forms in ASDs has been extensively researched.
- Do film coatings affect the physical stability of oral tablets containing ASDs?
- The influence of different excipients on the conversion of amorphous drugs into their crystalline forms in ASDs has been extensively researched. However, there is limited knowledge examining the impact of film coating materials on the physical stability of oral tablet formulations containing ASDs.
- Are plasticizers effective in film coating?
- We demonstrated the effect of plasticizers by comparing two commonly used plasticizers, triacetin, and PEG 3350, found in film coating materials. A tri-layered tablet was made to mimic a film coated tablet, which was used to study the leaching propensity between the two plasticizers from the top and bottom layers to the tablet's core.
