Use of surfactants as plasticizers in preparing solid
Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: selection of polymer-surfactant combinations using solubility parameters and testing the processability Authors Alazar N Ghebremeskel 1 , Chandra Vemavarapu , Mayur Lodaya Affiliation
Use of surfactants as plasticizers in preparing solid
Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: Selection of polymer–surfactant combinations using solubility parameters and testing the processability - ScienceDirect International Journal of Pharmaceutics Volume 328, Issue 2, 10 January 2007, Pages 119-129
Use of surfactants as plasticizers in preparing solid
Purpose: The purpose of the study is to evaluate the effect of surfactant-plasticizers on the physical stability of amorphous drug in polymer matrices formed by hot melt extrusion. Method: Solid dispersions of a poorly soluble drug were prepared using PVP-K30, Plasdone-S630, and HPMC-E5 as the polymeric carriers and surfactants as plasticizers.
Use of Surfactants as Plasticizers in Preparing Solid
Solid dispersions of a poorly soluble drug were prepared using PVP-K30, Plasdone-S630, and HPMC-E5 as the polymeric carriers and surfactants as plasticizers. The solid dispersions were produced by hot melt extrusion at temperatures 10°C above and below the glass transition temperature (Tg) of the carrier polymers using a 16 mm-Haake Extruder.
Use of Surfactants as Plasticizers in Preparing Solid
Use of Surfactants as Plasticizers in Preparing Solid Dispersions of Poorly Soluble API: Stability Testing of Selected Solid Dispersions Ghebremeskel, Alazar; Vemavarapu, Chandra; Lodaya, Mayur Pharmaceutical Research , Volume 23 (8) – Jul 27, 2006 Read Article Download PDF Share Full Text for Free 9 pages Article Details Recommended References
- Are surfactants good plasticizers?
- By and large, the surfactants appear to be promising plasticizers to produce solid dispersions by hot melt extrusion, in so doing improving dissolution rate without compromising the physical stability of the systems. ...
- Are surfactants promising plasticizers to produce solid dispersions by hot melt extrusion?
- By and large, the surfactants appear to be promising plasticizers to produce solid dispersions by hot melt extrusion, in so doing improving dissolution rate without compromising the physical stability of the systems.
- Do surfactants cause plasticization?
- The thermal analysis of the solid dispersions suggested that the surfactants caused plasticization, manifesting in reduction of (a) Tm of API, (b) Tg of the polymers, and (c) the combined Tg of the solid dispersion formed from quench cooling.
- Do surfactants cause solvation/plasticization in API-polymer-surfactant blends?
- Thermal analysis of the API-polymer-surfactant blends suggested that the surfactants caused solvation/plasticization, manifesting in reduction of (i) the melting (T (m)) of API (ii) T (g) of the polymers and (iii) the combined T (g) of the solid dispersion formed from quench cooling.
- Can surfactants be used as plasticizers for API dispersions?
- Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: selection of polymer/surfactant combinations using solubility parameters and testing the processability. Accepted July 11, 2006 to Int. J. Pharm. (2006). A. Dakkuri, H. G. Schreoeder, and P. P. Deluca. Sustaining release from inert wax matrices. II.
- Can surfactants be used as plasticizers for carrier polymers?
- The results of the study demonstrated that surfactants such as Tween-80 and Docusate sodium could be used as plasticizers for the various carrier polymers when hot-melt extrusion technique is employed. The authors are grateful to Dr. Zeri Teweldemedhin and Mr. William Polak for their assistance and valuable discussions.
