Assessment of reproductive and developmental effects of DINP
Overall scores between 246 and 350 indicate limited evidence for adverse effects thus supporting a classification as a category 2 reproductive toxicant. Overall scores above 351 confirm strong evidence for induction of adverse effects and a classification as a category 1B reproductive toxicant (Dekant and Bridges, 2016).
Assessment of reproductive and developmental effects of DINP
Quantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores for quality and observed toxicity. This QWoE-methodology was applied to the reproductive toxicity data on dii
Assessment of reproductive and developmental effects of DINP
On the other hand, DINP and diisodecyl phthalate (DIDP), even if present at high concentrations (8.87 and 5.91%, respectively), have only limitations for applications related to toys and...
EPA Fails to Regulate Chemicals That Disrupt Sexual Development
Between 2012 and 2015, as much as 500 million pounds of DINP was made or imported each year, according to the most recent numbers available from the EPA. Companies add DINP to hundreds of...
EPA Proposes Adding DINP to List of Toxic Chemicals
In the proposed rule, EPA proposes listing DINPs based on its “review of the available carcinogenicity data” which leads it to “conclude that DINP can reasonably be anticipated to cause cancer in...
- Does DINP affect sexual function?
- It is therefore evident that there is no “clear evidence of an adverse effect on sexual function… in the absence of other toxic effects” and a classification of DINP into Cat. 1B or 2 according to CLP is neither supported by a narrative approach nor by the QWoE applied here.
- Is a qwoe a reliable Toxicity database based on DINP and DCHP?
- The purpose of the application of a QWOE to the toxicity database on DINP, DCHP, and DnHP was to assess the robustness of the QWOE-methodology and the relevance of reported effects in the scientific literature in a transparent, consistent and scientifically justified way, using predetermined scores for quality and relevance/effects.
- Does DINP affect fertility?
- Effects of DINP on fertility-related parameters were only reported in two studies ( Boberg et al., 2011, Kwack et al., 2009 ). Kwack et al., 2009 reported significantly lowered sperm counts and motility of epididymal sperm after a four-week treatment of adult rats with a single dose level of 500 mg DINP/kg bw/day by daily gavage.
- Does DINP affect sperm number?
- The study suffers from the use of a single dose level and unclear reporting regarding use of concurrent controls. Moreover, the changes in sperm number only had a statistical significance level of <0.05 and general toxicity of DINP has been reported to occur at dose levels above ∼200 mg/kg bw/day ( ECHA/RAC, 2013 ).
- Does DINP increase sperm motility?
- Boberg et al., 2011 assessed reproductive parameters in male rats exposed in utero to doses of up to 900 mg DINP/kg bw/day. Sperm analysis at PND90 showed an increase in sperm count only the highest dose and a statistically significant, but not dose-related decrease in sperm motility at the 600, 750, and 900 mg/kg bw/day.
