5. What health effects can DBP cause in laboratory animals?
Dibutylphthalate is rapidly absorbed and excreted after oral administration as was demonstrated in studies in laboratory animals. Up to more than 90% of oral doses given to rats or hamsters was excreted in urine within 24-48 hours. Fecal excretion is low (1.0-8.2%). Also in man oral absorption of DBP takes place.
Phthalate Di-butyl phthalate - GreenFacts
In laboratory animals (as for DIDP and DINP) DBP mainly affects the liver but humans are thought to be much less sensitive to these liver effects. DBP also reduces the number and birth weight of rat offspring. Studies on developing rats show that DBP adversely affects development of the reproductive system in males.
Disinfection By-products (DBPs) Factsheet | National
How DBPs Affect People’s Health Chronic exposure to DBPs may increase risk of cancer. Humans exposed to unusually large amounts of some DBPs could experience liver damage and decreased nervous system activity. Levels of DBPs in the U.S. Population
EWG Skin Deep | What is DIBUTYL PHTHALATE
In animal studies, exposure to DBP during gestation causes infertility, cryptorchidism and problems in sperm development, adverse effects similar to human testicular dysgenesis syndrome. Prenatal exposure to DBP has been associated with anatomical changes in the reproductive system development in baby boys.
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Phthalates have been studied extensively in animals, and DBP and DEHP have been shown to be developmental and reproductive toxicants in laboratory animals. While the data in humans are
- What are the teratogenic effects of DBP?
- The embryotoxic effects of DBP on laboratory animals included mainly an increase in fetal resorption and a decrease in live births. The teratogenic effects of DBP also manifest as skeletal malformations in fetuses, malformations of male gonads and other genital effects.
- Does DBP affect reproductive organ weight?
- In the three subgroups, low dose (<100 mg/kg/d), postnatal, and exposure days (>15 days), we did not observe a significant correlation between DBP and reproductive organ weight. In view of the endocrine disrupting effects of DBP, this result exceeded our expectations.
- How does DBP affect sperm?
- On the one hand, DBP had an endocrine-disrupting effect, which leads to a significant decrease in testosterone. The decrease of testosterone level may lead to the interruption of the connection between germ cells and sertoli cells, resulting in the decrease of live sperm (Chuang et al., 2020).
- Does DBP affect reproductive indicators?
- Conclusion: Our research demonstrated that DBP may be negatively associated with reproductive-related indicators, especially at Gestation exposure period and middle dose (100–500 mg/kg/day).
- Does di-n-butyl phthalate (DBP) affect testosterone biosynthesis?
- Adult exposure to Di-N-butyl phthalate (DBP) induces persistent effects on testicular cell markers and testosterone biosynthesis in mice K. Martins, B. Applegate, B. Hagedorn, J. Kennish, P. Zwollo
- Does DBP work in the reproductive system?
- Many studies have employed animal models to explore the function of DBP in the reproductive system and have obtained preliminary results. But, the experimental results were controversial because of differences in animal models, dosages, and methods of administration.
